ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS

Authors

  • Mariele Andrade do Nascimento Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Daniela Silva Barroso de Oliveira Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Alfenas, MG, Brazil
  • Caio Luiz Bitencourt Reis Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Alfenas, MG, Brazil
  • Letícia Maria Wambier School of Health and Biological Sciences, Positivo University, Curitiba, PR, Brazil
  • Karla Carpio Horta Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil
  • Fabio Lourenço Romano Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil
  • Léa Assed Bezerra da Silva Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil
  • Raquel Assed Bezerra da Silva Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil
  • Paulo Nelson-Filho Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil
  • Erika Calvano Kuchler Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto/University of São Paulo, Ribeirão Preto, SP, Brazil

DOI:

https://doi.org/10.29327/24816.4.2-2

Keywords:

Genetic Polymorphism; Angle class III; Prognathism;, Single nucleotide; Somatotropin-binding protein.

Abstract

Objective: Through a systematic review and meta-analysis, the aim this study was evaluating the association between the P561T polymorphism in GHR (rs6184) with skeletal Class III malocclusion in different populations. Methods: A broad search for studies was conducted using the databases: PubMed, Web of Science, Scopus, Cochrane, Google Scholar and Open Grey until December 2018. The study design according to PECOS was: P-Orthodontic patients; E- polymorphism P561T in GHR; C- absence of polymorphism P561T in GHR; O- linear dimension alterations in maxilla and mandibular measurements; S- Cross-sectional studies. The selected studies were qualified by 10-point scoring sheet methodological quality. The subgroups evaluation was performed according to the linear measurements evaluated in two or more studies, as follows: body height, N-S, A’-PTM’, Gn-Go, Pog’-Go, and Co-Go.A fixed effect model was used and the mean differences were performed using the inverse-variance meta-analysis. The I2 (95%) was used to measure statistical heterogeneity between studies, where I2 values of 25%, 50%, and 75% signified low, medium, and high heterogeneity, respectively. Results: The initial search identified 146 studies. After excluding duplicate
abstracts, 138 were selected. Seven studies were included in the systematic review. Only one study was classified as having low methodological quality. Three studies were included in the meta-analysis. The meta-analysis demonstrated an association between the Co-Go linear measure and CC genotype (p<0.0001), with a mean difference and confidence interval of 3.79 [2.06, 5.52]. CC was associated with greater mandibular
height. Conclusion: The polymorphism P561T in GHR is associated with Co-Go measurement in Asians, with low level of evidence.

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Published

2019-10-12

Issue

Vol. 4 No. 2: May-August 2019

Section

Review