BIOMARCADORES DO ESTRESSE OXIDATIVO EM PACIENTES COM DIABETES MELLITUS TIPO 2 E PERIODONTITE: UMA ANÁLISE BIBLIOMÉTRICA

Abstract

Objective: identify and describe the profile of publications on oxidative stress biomarkers in individuals with type 2 diabetes mellitus and periodontitis. Sources of Data: bibliographic searches were carried out on the following databases: PubMed, Scopus, Web of Science, Cochrane library, Embase and LILACS/BBO, without restrictions on language or publication date. Data on titles, years of publication, keywords, countries of origin, authors and their collaborations, types of study, periodicals of publications, types of biomarkers and association between variables were extracted and analyzed using VantagePoint™ software. Synthesis of Data: A total of 38 studies met the eligibility criteria (human studies that evaluated oxidative stress markers in patients with DM2 and periodontitis, excluding initial clinical trial protocols, preclinical studies, ex-vivo studies, case reports and letters to the editor), being 68.42% observational studies and 31.58% interventional studies. India had most of the works published on the topic (50%) and Journal of Periodontology was the periodical that concentrated the majority of publications (18.42%). The publications began in 2005, with an increase in the number of publications in the following decades. In studies, the most researched biomarkers were total antioxidant capacity (26.31%), followed by superoxide dismutase-1 (23.68%) and catalase (21.05%). A positive association between oxidative stress biomarkers and periodontal disease was found in 37 articles (97.36%). Conclusion: studies on oxidative stress have shown an increase in the number of publications from year to year, being India the main protagonist of publications and the results obtained promising tools to evaluate the relationship between these diseases.